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DHEA Depression Studies and Links Page  

DHEA (dehydroepiandersterone), a non-prescription dietary supplement, may be an effective treatment for midlife-onset major and minor depression. Sexual functioning scores relative to baseline were also improved.
 
 

Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression

Study Design: A double-blind, randomized, placebo-controlled, with crossover treatment was conducted at The National Institutes of Mental Health Midlife Outpatient Clinic in the National Institute of Health Clinical Center, Bethesda MD, USA. 23 men and 23 women in aged 45 to 65 years with midlife-onset major or minor depression was given six weeks of DHEA therapy, 90 mg per day for 3 weeks and 450 mg per day for 3 weeks, and 6 weeks of placebo.

Results  Six weeks of DHEA administration was associated with a significant improvement in the 17-Item Hamilton Depression Rating Scale and the Center for Epidemiologic Studies Depression Scale ratings compared with both baseline (P<.01) and 6 weeks of placebo treatment (P<.01). A 50% or greater reduction in baseline Hamilton Depression Rating Scale scores was observed in 23 subjects after DHEA and in 13 subjects after placebo treatments. Six weeks of DHEA treatment also was associated with significant improvements in Derogatis Interview for Sexual Functioning scores relative to baseline and placebo conditions.

Conclusion  We find DHEA to be an effective treatment for midlife-onset major and minor depression.
Source: Schmidt et. al Arch Gen Psychiatry. 2005;62:154-162. see full abstract   cached abstract

 
 
Rev Med Brux. 2001 Sep;22(4):A381-6. Related Articles, Links

[DHEA: orthodox or alternative medicine?]

[Article in French]

Cogan E.

Service de Medecine Interne Generale, Hopital Erasme, U.L.B.
 
...recent studies confirmed positive effects of DHEA administration in healthy elderly people, mostly more than 70 years old women, on skin, bone density, muscle strength and several neuropsychological symptoms. Positive effects on sexual interest and satisfaction and sense of well-being are more consistent in elderly women than in men. The recommended administered dose is 25 mg to 50 mg once a day in women and 100 mg in men.
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Clinical uses and misuses of dehydroepiandrosterone.
Curr Opin Pharmacol. 2003 Dec;3(6):635-41. Review.

....Evidence is accruing in support of dehydroepiandrosterone supplementation in adrenal insufficiency, hypopituitarism, osteoporosis, systemic lupus erythematosus, depression and schizophrenia. ...

see full abstract  cached abstract
 
Double-blind treatment of major depression with dehydroepiandrosterone.

Wolkowitz OM, Reus VI, Keebler A, Nelson N, Friedland M, Brizendine L, Roberts E.

Department of Psychiatry, University of California Medical Center, San Francisco, USA.

CONCLUSIONS: These results suggest that DHEA treatment may have significant antidepressant effects in some patients with major depression. Further, larger-scale trials are warranted.

see full study abstract    see full study text in html    see full study in pdf    cached abstract
 
 


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Last modified: February 26, 2005